Photobiomodulation

Red and near-infrared (NIR) light can influence mitochondria through a process known as photobiomodulation. These wavelengths penetrate tissues and are absorbed primarily by cytochrome c oxidase (CcO), a key enzyme in complex IV of the mitochondrial respiratory chain. This light absorption affects cellular metabolism in several ways.

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    ATP production

    CcO plays a crucial role in oxidative phosphorylation, where the proton gradient generated in the respiratory chain is used for the production of ATP. Red and NIR light increase the efficiency of this enzyme, facilitating electron transport and increasing ATP production. This results in more energy being available to the cell, promoting tissue regeneration and repair.

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    Nitric Oxide (NO)

    Red light and NIR can dissociate nitric oxide (NO) from CcO, which under normal conditions can inhibit the respiratory chain by competing with oxygen in the enzyme. By releasing NO, mitochondrial respiration is improved and ATP production is increased. The released NO can also act as a cellular signaling agent, promoting vasodilation and improving local blood circulation.

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    Reactive Oxygen Species (ROS)

    Stimulation by red and NIR light can also lead to a controlled increase in the production of reactive oxygen species (ROS). Although excess ROS is harmful, small amounts play important roles as signaling molecules, regulating cellular processes such as proliferation and repair.

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How is it defined?

Red Light Therapy?

It is a process in which red and near-infrared (NIR) light is applied to various parts of the body. It is a completely safe, painless and natural treatment for a wide variety of diseases and physiological problems.

Red light therapy involves using a device that emits these wavelengths with specific LED bulbs. These specially designed light devices can range in size from handheld to large enough to emit light that covers your entire body. Depending on which part of the body needs treatment, different types of red light therapy devices are available. The variety of devices available means that the devices can be tailored to the specific needs of the patient and provide the best possible results.

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How it works

What happens to the body when exposed to phototherapy?

The body’s cells improve their metabolism and experience reduced inflammation when effective red light therapy treatment is applied. Cells react to light therapy through a photochemical response. The application of red and near-infrared (NIR) light increases the production of adenosine triphosphate (ATP) in the treated area. ATP is produced in the mitochondria, often referred to as “the powerhouse of the cell,” as we learned in biology class.

When our cells are “stressed,” our ATP doesn’t work as well as it should. Nitric oxide molecules will bind to ATP, and as a result, our cells won’t perform as well. As light penetrates the cell’s mitochondria, the nitric oxide molecules that inhibit ATP break away from ATP and bind to oxygen molecules. As a result, the mitochondria and ATP start working efficiently again.

When our cells are “stressed”, ATP does not function optimally. In these situations, nitric oxide molecules bind to ATP, impairing its performance. When light penetrates the mitochondria, the nitric oxide molecules that inhibit ATP dissociate from it and bind to oxygen molecules. This allows the mitochondria and ATP to regain their optimal functionality. The release of nitric oxide molecules from the cells has a vasodilatory effect, which in turn stimulates blood flow to the treated site and surrounding areas.

In this way, communication between the cell nucleus and the remaining internal structures is optimized, resulting in an increase in cellular energy. Increased blood flow to the treated area contributes to the reduction of inflammation and pain, among other significant benefits.

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Who can try it?

The benefits of Red Light Therapy?

Red light therapy can benefit everyone as a painless solution to a wide range of health issues and mood disorders. It is ideal for those looking to reduce pain and inflammation, as well as those who want to increase the body’s ability to heal itself. Red light therapy is also an excellent option for those looking for alternatives to pharmaceutical or surgical treatments. It can even be performed before or after physical activity to maximize its benefits.

While the following list does not include every category of people who have benefited from red light therapy, it does include some of the groups of patients who have experienced success and health benefits after starting this type of treatment.

  • People seeking Skin Rejuvenation

    Phototherapy is a valuable, non-invasive treatment plan for those looking to combat signs of aging. Red light therapy helps restore the skin’s youthful appearance by stimulating cell regeneration. Sun exposure is one of the main causes of skin aging and sagging. Red light therapy combats these signs of aging by increasing collagen levels and improving skin elasticity.

    Red light therapy can help reduce the appearance of wrinkles by increasing collagen levels in the skin. As a result, skin elasticity improves. LLLT (Laser Led Light Therapy) is an excellent option for those who want to improve the appearance of their skin without reported side effects and without treatment downtime.

    In addition to LLLT, red light therapy is quickly becoming popular among people seeking a more youthful glow. Today, there are light therapy devices specifically designed to combat wrinkles and other signs of skin aging.

  • Those with Mood and Anxiety Disorders

    Studies have shown the benefits of red light therapy in increasing melatonin levels, which contributes to improving mood and sleep quality, as well as reducing anxiety. With mental health increasingly being discussed, it is essential to be aware of all the treatment options available.

    Red light therapy's ability to improve cellular functions also contributes to increased cognitive function. Effective treatment can help alleviate problems associated with depression and anxiety. In terms of improving mental health and well-being.

  • Pain Relief and Muscle Recovery

    Probably the most common reasons people seek out LLLT or red light therapy and discover its benefits are for treating injuries, joint pain, and other soft tissue issues. From painful lower back pain to arthritis, studies have repeatedly demonstrated the benefits of red light therapy as an effective treatment for healing the body.


    In addition to its ability to promote rapid soft tissue recovery, red light therapy is also beneficial for muscle recovery. Surprisingly, studies suggest that it can improve athletic performance both before and after exercise!


    Phototherapy benefits athletes by increasing muscle mass gained after training, while speeding up recovery.

  • Patients with Neurological Problems

    Phototherapy has been shown to be successful in treating mild to moderate dementia and the symptoms of Alzheimer's disease. One hypothesis for the cause of Alzheimer's disease is the presence of amyloid deposits in the brain. These deposits consist of an abnormal clumping of proteins that cause nerve damage. Phototherapy has been shown to successfully reduce the volume of these deposits in neuroblastoma cells.

    After using red light therapy treatments, patients saw significant improvements in assessment scores used to monitor the progression of Alzheimer's disease. Patients also experienced significant improvements in their physical and emotional well-being, reporting improved sleep, reduced anxiety, and improved overall fitness, with no reported adverse side effects."

  • Fibromyalgia Patients

    Phototherapy is an effective treatment option for people with fibromyalgia or postherpetic neuralgia. These problematic and difficult-to-treat conditions are often debilitating. If left untreated, pain can persist and become an ongoing, long-term problem.

    Patients seeking a pain management solution should consider LLLT. When red light therapy is targeted at painful trigger points associated with fibromyalgia, patients notice a significant decrease in pain levels, which in turn aids in recovery and encourages reversal of the painful and exhausting condition."

  • Wound Healing

    Red and infrared light therapy have been shown to be effective in promoting wound healing in the skin. Light therapy has been shown time and again to be beneficial in treating wounds by decreasing inflammation and stimulating increased collagen production and angiogenesis. Depending on the type of skin or muscle damage a person is dealing with, either LED red light therapy devices or LLLT infrared tools will be used as appropriate treatment options.

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Final Considerations

Red light and NIR act beneficially on mitochondria by optimizing energy production, improving blood flow and regulating cell signaling processes.